o A1M Pharma utvecklar biologisk läkemedelskandidat som bygger på kroppseget När Bo Åkerström, en av bolagets grundare, 1974 började.

The last eight years, at A1M Pharma AB, I have been occupied by taking a Supervisor: Prof Bo Åkerström, Cell and molecular Biology, Lund University

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift. Bo Åkerström har ägnat hela sitt yrkesliv åt att förstå och beskriva proteinet A1M och de senaste tio åren har vi studerat det i laboratoriet som möjligt läkemedel. I ett flertal olika djurmodeller har vi kunnat visa goda behandlingsegenskaper, bland annat genom att proteinet förhindrar hemoglobinets skadliga effekter på moderkakan, blodkärl och njurar. A1M Pharma meddelar att bolagets medgrundare Bo Åkerströms forskargrupp har tilldelats ett anslag om 1,2 MSEK från Vetenskapsrådet. Anslaget är öronmärkt till prekliniska studier i sen fas om njurskydd med läkemedelskandidaten ROSgard ™ vid strålbehandling. Studierna bedrivs i samarbete mellan professor Åkerström och A1M Pharma. 2015-02-04 A1M Pharma meddelar att bolagets medgrundare Bo Åkerströms forskargrupp har tilldelats ett anslag om 1,2 MSEK från Vetenskapsrådet.

Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates.

A1M Pharma meddelar att bolagets medgrundare Bo Åkerströms forskargrupp har tilldelats ett anslag om 1,2 MSEK från Vetenskapsrådet. Anslaget är öronmärkt till prekliniska studier i sen fas om njurskydd med läkemedelskandidaten ROSgard(tm) vid strålbehandling. Studierna bedrivs i samarbete mellan professor Åkerström och A1M Pharma.

Bo Åkerström är inte bara professor, han är frontfigur i bandet Torsson också. Bo Åkerström's 186 research works with 5,544 citations and 7,942 reads, including: biomolecules-11-00263-ag.png and Bo Åkerström. 2 * 1. (tgA1M) and tagless A1M (ntA1M) in a rather similar fashion although the His-tag is very likely involved into coordination with iron of the heme molecule.

and Bo Åkerström. 2 * 1. (A1M), a small lipocalin protein found in plasma and tissues, has been identiﬁed as a heme. 1. and radical scavenger that may participate in the

1, Finally, A1M bound to purified collagen I (K(d) = 0.96×10(-6) M) and could inhibit and repair the destruction of collagen fibrils by heme and reactive oxygen species. The results suggest that A1M may have a physiological role in protection of skin cells and … 2019-11-01 and Bo Åkerström. 2 * 1. (tgA1M) and tagless A1M (ntA1M) in a rather similar fashion although the His-tag is very likely involved into coordination with iron of the heme molecule. α1-microglobulin (A1M) is a small protein present in vertebrates including humans. It has several physiologically relevant properties, including binding of heme and radicals as well as enzymatic reduction, that are used in the protection of cells and tissue. Research has revealed that A1M can ameliorate heme and ROS-induced injuries in cell cultures, organs, explants and animal models.

Maintenance of energy delivery during cell death is therefore crucial, but the mechanisms t 2012-07-25 Human Anti-Oxidation Protein A1M—A Potential Kidney Protection Agent in Peptide Receptor Radionuclide Therapy By Jonas Ahlstedt, Thuy Tran, Sven-Erik Strand, Magnus Gram and Bo Åkerström … Vitreous levels of oxidative stress biomarkers and the radical-scavenger α1-microglobulin/A1M in human rhegmatogenous retinal detachment By Martin Cederlund, Fredrik Ghosh, Karin Arnér, Sten Andréasson and Bo Åkerström A1M/α1-Microglobulin Protects from Heme-Induced Placental and Renal Damage in a Pregnant Sheep Model of Preeclampsia By Lena Wester-Rosenlöf, Vera Casslén, Josefin Axelsson, Anneli Edström-Hägerwall, Magnus Gram, Madlene Holmqvist, Martin E. Johansson, Iréne Larsson, David Ley, Karel Marsal, Matthias Mörgelin, Bengt Rippe, Sigurbjörg Rutardottir, Behnaz Shohani, Bo Åkerström and A1M Ameliorates Preeclampsia-Like Symptoms in Placenta and Kidney Induced by Cell-Free Fetal Hemoglobin in Rabbit By Åsa Nääv, Lena Erlandsson, Josefin Axelsson, Irene Larsson, Martin Johansson, Lena Wester-Rosenlöf, Matthias Mörgelin, Vera Casslén, Magnus Gram, Bo Åkerström … A1M Pharma AB engages in the research, development, and commercialization of medical treatment and diagnosis based on alpha-1-microglobulin. It focuses on the … Professor Bo Åkerström berättar hur forskningen om proteinet A1M har växt fram under 30 år. Bo Åkerström har ägnat hela sitt yrkesliv åt att förstå och beskriva proteinet A1M och de senaste tio åren har vi studerat det i laboratoriet som möjligt läkemedel.
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Professor Bo Åkerström berättar hur forskningen om proteinet A1M har växt fram under 30 år. The cysteine 34 residue of A1M/1-microglobulin is essential for protection of irradiated cell cultures and reduction of carbonyl groups. Rutardottir, Sigurbjörg; Nilsson, E J C; Pallon, Jan; Gram, Magnus; Åkerström, Bo Published in: Free Radical Research DOI: 10.3109/10715762.2013.801555 2013 Link to publication Citation for published Together with his colleague, Bo Åkerström, professor of infection medicine, Stefan Hansson started the studies on A1M several years ago and observed that A1M stopped the leakage of protein in the kidneys. They also saw that the placenta was repaired and that the destroyed structures in the cells’ smallest components were restored. Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates.

A1M Pharma meddelar att bolagets medgrundare Bo Åkerströms forskargrupp har tilldelats ett anslag om 1,2 MSEK från Vetenskapsrådet. Anslaget är öronmärkt till prekliniska studier i sen fas om njurskydd med läkemedelskandidaten ROSgard ™ vid strålbehandling. Studierna bedrivs i samarbete mellan professor Åkerström och A1M Pharma.
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Mr. Bo Åkerström is an Independent Director at A1M Pharma AB and a Partner at Rim & Reson Musikproduktion HB. He is on the Board of Directors at A1M Pharma AB and Preelumina Diagnostics AB.

The cysteine 34 residue of A1M/1-microglobulin is essential for protection of irradiated cell cultures and reduction of carbonyl groups. Rutardottir, Sigurbjörg; Nilsson, E J C; Pallon, Jan; Gram, Magnus; Åkerström, Bo Published in: Free Radical Research DOI: 10.3109/10715762.2013.801555 2013 Link to publication Citation for published Bo Åkerström har ägnat hela sitt yrkesliv åt att förstå och beskriva proteinet A1M och de senaste tio åren har vi studerat det i laboratoriet som möjligt läkemedel. De kliniska studierna blir avgörande. Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates. The protein was discovered 40 years ago and its physiological role remained unknown for a long time. A series of recent publications have demonstrated that A1M is a vital part of tissue hou … Early reports proposed an immunoregulatory role of A1M (Babiker-Mohamed et al., 1990a; Åkerström et al., 2000), but more recent reports have presented data of enzymatic reductase activity as well as heme- and radical binding functions, which reconceptualized the biological role to a housekeeping protein responsible for cleaning of tissues and antioxidant protection (Åkerström and Gram, 2014).